Introduction
The article Alkoxysulfenylation of Alkenes: Development and Recent Advances by Cao et al. reviews the academic literature on the dysfunctionalization of carbon-carbon double bonds. As a target method to consider, the authors evaluate alkoxysulfenylation of alkenes as a mechanism to obtain b-alkoxysulfides at minimal cost and through the use of available reagents (Cao et al. 32513).
Discussion
In support of the updated method, traditional approaches to this work are evaluated. As Cao et al. argue, the necessary compounds were obtained by reacting thiophenol sodium salts with b-alkoxyhaloalkoxides (32514). However, the criticism of this mechanism speaks in favor of the optimized approach. The multi-step operation and the low diversity of substrates involved suggest that the alkoxysulfenylation of alkenes via the above algorithm is the most convenient technique in terms of productivity/cost ratio (Cao et al. 32514). As proof of this argument and a reflection of the corresponding reactions, numerous formulas, and calculations are presented, demonstrating the course of chemical reactions. In addition, schematic reflections of molecular processes are shown to confirm the rationality and ease of use of the considered method to replace outdated techniques and ineffective chemical experiments.
The features of the alkoxysulfenylation process are shown as mechanisms that are available through the involvement of specific resources necessary for the reactions in question. Since b-alkoxy sulfides are the target substances to obtain, the described chains are characterized as relatively simple. For instance, according to Zhang et al., these chemical reactions involving styrene can have moderate yields (1198). Thus, working with alkenes allows for not only achieving the desired result but also addressing address the required capacities through optimized chemical reactions. Cao et al. emphasize intermolecular bonds and note the value of the synthesis approach used while drawing attention to the impossibility of obtaining the same results for functionalized structures (32519). References to the historical context of developments in this area help compare the proposed method with traditional practices and identify the obvious advantages of the analyzed approach. Some studies of cyclization products show that special compounds of alkenes, namely cis-alkenes, contribute to achieving higher selectivity values than trans-alkenes (Cao et al. 32521). These findings are an essential addition to the synthesis strategy and allow for drawing conclusions regarding the application of the proposed reactions to solve the tasks set.
Through calculations and formulas, the dysfunctionalization of alkenes is evaluated as one of the most convenient ways to produce complex molecular bonds. In the study by Bao et al., the authors noted the value of work in this direction, but due to the limited number of available findings, there were no unequivocal conclusions (4528). Due to Cao et al.’s analysis, the relevant arguments for the application of the technology under consideration are given. The researchers note the value of this approach not only from an intermolecular but also from an intramolecular perspective, mentioning the comprehensiveness of the reviewed data and evidence in support of this method (Cao et al. 32524).
Conclusion
As a limitation, styrene derivatives are judged to be incapable of evaluating the range of alkene applications. As potential avenues for future research, work is proposed to identify the relationships between the accompanying elements of chemical compounds within the presented alkene groups with a focus on aliphatic alcohols. A large number of references to credible resources and studies from different years enhance the practical value of the findings and increase the relevance of the proposed method of chemical synthesis.
Works Cited
Bao, Xiazhen, et al. “Radical-Mediated Difunctionalization of Styrenes.” Synthesis, vol. 51, vol. 24, 2019, pp. 4507-4530.
Cao, Yan, et al. “Alkoxysulfenylation of Alkenes: Development and Recent Advances.” RSC Advances, vol. 11, no. 51, 2021, pp. 32513-32525.
Zhang, Rongxing, et al. “NaI-Mediated Acetamidosulfenylation of Alkenes with Bunte Salts as Thiolating Reagent Leading to β-Acetamido Sulfides.” Synlett, vol. 28, no. 10, 2017, pp. 1195-1200.