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Coagulation Disorders in Pathologic Conditions

Coagulation disorders are abnormal bleeding or clotting, which can lead to life-threatening conditions such as blood loss from minor injuries or thrombosis. Although some of these disorders are congenital, they can also be acquired and be comorbid with pathological conditions. For instance, vitamin K plays a significant part in the formation of clotting factors (Girolami et al., 2018). The particular interactions of such vitamin K-dependent clotting factors are recent findings; however, research indicates that some of these factors can be associated with both bleeding and thrombosis (Girolami et al., 2018). Therefore, conditions that involve vitamin K deficiency can cause bleeding disorders.

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Coagulation disorders can also be attributed to conditions affecting the liver, such as diabetes. Similar to above, the physiology of the relation between diabetes and such disorders is not currently fully understood (Sobczak & Stewart, 2019). Patients with type 1 and type 2 diabetes show abnormal concentrations and activity of coagulatory proteins, leading to increased likelihood of coagulation disorders, including life-threatening conditions (Sobczak & Stewart, 2019). Furthermore, the prognosis after cardiovascular events is generally poor in diabetic patients (Sobczak & Stewart, 2019). Diabetes also causes hyper-activation of platelets, which leads to increased coagulation, a higher likelihood of clot formation and thrombosis (Sobczak & Stewart, 2019). These abnormalities can be controlled to some extent with glycemic management, which is normally a part of diabetes management strategies (Sobczak & Stewart, 2019). It is also important to note that the particular coagulation factors are different between type 1 and type 2 diabetes, leading to different management strategies (Sobczak & Stewart, 2019). Ultimately, considering the increasing prevalence of diabetes mellitus in the populace, understanding its relationship with coagulation disorders is a critical concern.

References

Girolami, A., Ferrari, S., Cosi, E., Santarossa, C., & Randi, M. L. (2018). Vitamin K-dependent coagulation factors that may be responsible for both bleeding and thrombosis (FII, FVII, and FIX). Clinical and Applied Thrombosis/Hemostasis, 24(9_suppl), 42S-47S. 107602961881110. Web.

Sobczak, A. I. S., & Stewart, A. J. (2019). Coagulatory Defects in Type-1 and Type-2 Diabetes. International Journal of Molecular Sciences, 20(24), 6345. Web.

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